Gröschel et al. showed that recurrent inv(3)(q21q26.2) or t(3;3)(q21;q26.2) [inv(3)/t(3;3)] rearrangements, which lead to aberrant expression of the proto-oncogene EVI1 in AML, are caused by the translocation of an endogenous enhancer which usually regulates GATA2 (Table 1) (Gröschel et al., 2014). Here, MECOM is linked to acute myeloid leukemia.