RUNX1 and acute myeloid leukemia: Gröschel et al. showed that recurrent inv(3)(q21q26.2) or t(3;3)(q21;q26.2) [inv(3)/t(3;3)] rearrangements, which lead to aberrant expression of the proto-oncogene EVI1 in AML, are caused by the translocation of an endogenous enhancer which usually regulates GATA2 (Table 1) (Gröschel et al., 2014).