MYC and acute lymphoblastic leukemia: Off-target activity of these cellular processes has been attributed to chromosomal translocations, such as translocation of the T cell receptor locus with its strong endogenous enhancers into close regulatory proximity to the oncogenes LMO2, TAL1 and TAL2 in T-ALL, and the AID-dependent MYC/IGH translocations in Burkitt's lymphoma (Marculescu et al., 2002; Robbiani et al., 2008).