Notably, the authors showed that TAL1 is located in its own insulated neighbourhood in Jurkat cells, with one CTCF site found in the middle of a neighbouring gene called STIL, and the other located in a noncoding region 3′ of TAL1. Interestingly, a subset of primary T-ALL patient samples appeared to have genomic deletions of the CTCF site within STIL, which in effect destroys the insulation boundary of the neighbourhood. Here, CTCF is linked to acute lymphoblastic leukemia.