Indeed, recruitment of the TAL/LMO complex to this noncoding site upstream of TAL1 was validated using ChIP-seq (Box 1) in the Jurkat T-ALL cell line and the locus was enriched for H3K27 acetylation, a marker of an active enhancer facilitated by intrinsic CBP histone acetyltransferase activity. The gene discussed is CREBBP; the disease is acute lymphoblastic leukemia.