TAL1 and acute lymphoblastic leukemia: Notably, the authors showed that TAL1 is located in its own insulated neighbourhood in Jurkat cells, with one CTCF site found in the middle of a neighbouring gene called STIL, and the other located in a noncoding region 3′ of TAL1. Interestingly, a subset of primary T-ALL patient samples appeared to have genomic deletions of the CTCF site within STIL, which in effect destroys the insulation boundary of the neighbourhood.