In an independent study, Hu et al. used whole-genome sequencing (WGS) of 31 paediatric T-ALL patients and matched germline samples to identify the previously discussed somatically acquired noncoding variants at the TAL1 and LMO2 loci, but also the LMO1 promoter mutation (Table 1) (Hu et al., 2017). The gene discussed is TAL1; the disease is acute lymphoblastic leukemia.