CD4 and acute myeloid leukemia: In addition, in a single cell expression data from one M6 AML patient [53], we found TGFB1 to be highly expressed in three major cell clusters, including CD4+CD14+ monocytes, PRSS57+MYC+ neutrophils, and CD3+CD7+ T cells (Additional file 2: Figure S12), suggesting a complex regulation of IgA2 B cell proliferation in AML.