Notably, genomic aberrations of Phosphoinositide 3-kinase (PI3K) pathway encoding genes including PIK3CA and PTEN were significantly more prevalent in endometrial tumors (P = 1.518 × 10−06 and P = 2.686 × 10−08, Fisher’s exact test; Additional file 1: Figure S1), suggesting potential therapeutic opportunities for PI3K targeted therapies [22, 25, 26]. The gene discussed is PIK3CA; the disease is endometrium neoplasm.