Afterwards, PDCs were subjected to systematic drug sensitivity screening against 37 anti-cancer agents, targeting major oncogenic pathways including receptor tyrosine kinase (RTK), histone deacetylase (HDAC), and poly (ADP-ribose) polymerase (Additional file 3: Table S2 and Additional file 1: Figure S3) [19]. This evidence concerns the gene NTRK1 and cancer.