As shown in Fig. 1, we found that patients with high serum IL-6 levels showed a poorer overall survival (OS) compared with patients with low IL-6 levels (Fig. 1a, P = 0.007), and had more early tumor recurrence (Fig. 1b, P = 0.0004 for IL-6 and Table 1, n = 144). This evidence concerns the gene IL6 and neoplasm.