AIM2 and neurodegenerative disease: Suppression of T1 IFN response by Aim2 and AIM2 proteins in the CNS may be important to keep the levels of the T1 IFN-inducible negative regulator proteins (murine p202 and human IFI16-β and POP3) below a threshold to suppress neuroinflammation-related neurodegenerative diseases (Table 1).