AIM2 and neurodegenerative disease: Because the ability of Aim2/AIM2 proteins to exert pro- and anti-inflammatory effects in the CNS may depend upon the genetic background, age, sex hormones, cell-type, and species-specific expression of the negative regulators of the Aim2/AIM2 inflammasome [49–52], here we discuss the role of these proteins in the development of neurodegenerative diseases.