TP53BP1 and neurodegenerative disease: Because the basal expression of the p202 protein (a negative regulator of the Aim2 inflammasome) is much higher in the B6.Sv129 mouse strain than the B6 strain [60], studies using the Aim2−/−.(B6.Sv129) mice are not very informative with respect to the precise role of the Aim2 protein in the development of neuroinflammation and neurodegenerative diseases.