By literature reviewing, among the five genes, four have been well documented in HCC, including: ALDOB [48–50], IGFBP3 [51–53], CYP2E1 [54–56] and TOP2A [57, 58], while AGXT was mostly studies in primary hyperoxaluria type 1 [59, 60], there are little reports of AGXT in HCC. Here, TOP2A is linked to primary hyperoxaluria type 1.