Among the 17 genes, 13 genes (SMAD2, PTK2, MAPK1, HDAC1, CDC25A, IGFI, FOS, ESR1, EGFR, SOCS3, SP1, YY1 and JUNB) have been identified as an HCC-related gene [73]. The gene discussed is ESR1; the disease is hepatocellular carcinoma.