After a preliminary check of these 43 articles, we included “Author”, “Year of publication”, “Country”, “Number of patients” (NP), “Number of significant genes” (NG),”Clinical tissue” (Tissue), “Contain adjacent tissue” (C&A), “Hepatitis B surface antigen” (HBs-Ag), “Hepatitis C antibody” (HCV-Ab), “Alcoholism “, “Tumor size” (TS),”Tumor differentiations” (TD), and “AFP” as the baseline variables to characterize the enrolled studies. This evidence concerns the gene RENBP and alcohol dependence.