According to a study about SPOP mutation frequency in prostate cancer across demographically diverse patient cohorts, the most frequently mutated residue was F133 (50%) followed by Y87 (15%), W131 and F102 (9%), F125 (3%), and K129, F104, and K135 (2%), other mutated residues are less frequent [27]. The gene discussed is SPOP; the disease is Familial prostate cancer.