Depletion of SPOP by short hairpin RNA (shRNA)-mediated knockdown or CRISPR/Cas9-mediated knockout in multiple prostate cancer cell lines resulted in a marked increase in the steady-state levels of endogenous Caprin1 (Fig. 2g, Additional file 1: Figure S2A-D)). The gene discussed is SPOP; the disease is Familial prostate cancer.