It will be interesting to explore whether upregulation of SG assembly is a universal phenomenon in various subtypes of prostate cancer or unique to the SPOP-mutated subtype, and whether other frequently mutated genes in prostate cancer, such as PTEN, FOXA1, PIK3CA, MED12, and TP53, are also involved in regulation of SG assembly. The gene discussed is PIK3CA; the disease is Familial prostate cancer.