ADRB2 and breast carcinoma: Additonally, It is reported that cancer cells inoculation in mice pretreated with ISO for 14 days can increase the number of bone lesions and tumors, and stimulation of the β2AR in host stromal cells mediated the stimulatory effect of ISO on breast cancer cell-bone metastasis [10], suggesting that β2AR signaling in osteoblasts is essential for cancer cell metastasis to bone.