Similarly, LY2510924, a CXCR4 inhibitor also antagonized the stimulatory effect of ISO on the cell migration and invasion of prostate cancer cells co-coltured with MC3T3 E1 cells (Additional file 2: Figure S2A-B) or primary osteoblasts (Additional file 2: Figure S2C-D). This evidence concerns the gene CXCR4 and prostate carcinoma.