Seven of these categories were directly involved in circulation development and related diseases, including trabecula carnea hypoplasia (6 PSG, e.g., ANKRD17, TGFBR3 and LATS2), hemorrhage (13 PSG, e.g., PLVAP, MGRN1 and EPAS1), thin myocardium (7 PSG, e.g., ANKRD17, TGFBR3 and WNK1), and cyanosis (11 PSG, e.g., YY1, NDST1 and NBEA). This evidence concerns the gene PLVAP and Abnormality of the skin.