For example, NAC decreased TGFβ signalling in fibroblasts [76]; cardiac fibrosis was decreased by NAC in a mouse model of heart failure [77]; NAC decreased fibrosis in soleus muscle in a murine model of peripheral arterial insufficiency [78]; and renal fibrosis was decreased by NAC in a model of dilated cardiomyopathy [79]. Here, TGFB1 is linked to heart failure.