In comparison, Emd−/y fibroblasts from EDMD patients grown randomly on fibronectin display a slightly more deformed nucleus with an NSI at 0.94 ± 0.01 (p < 0.01, Figure 4B,C), consistent with previous results in emerin-deficient mouse fibroblasts [21] and human muscle cells [38]. Here, EMD is linked to Emery-Dreifuss muscular dystrophy.