SELP and Hepatic fibrosis: More significant in this regard is the following study by Wynn et al. In P-selectin-deficient mice, hepatic fibrosis induced by the parasite Schistosoma mansoni and analyzed 16 weeks after infection was dramatically increased compared to livers of wild-type mice and correlated with a higher frequency of liver-infiltrating IL-13- and IFNγ-producing lymphocytes as well as a reduction in decoy IL-13 receptor expression.