Further investigation into the interconnection of obesity and NAFLD was carried out by Wang et al. in which their HPRD-based PPI networks revealed that compared to control, healthy-obese and steatotic subjects showed high degree of differential expression for the hub gene PRK-CA, which interacts with EGFR and CDC42 [113]. Here, CDC42 is linked to obesity due to melanocortin 4 receptor deficiency.