Through the use of WGCNA, a co-expression network modeling approach, to identify top modules and genes in NAFLD via transcriptomics, Lou et al. found several top hub genes including LUM, THBS2, FBN1, and EFEMP1, all of which were significantly upregulated in advanced fibrosing-NAFLD across several human cohorts and in ApoE−/− mice [103]. Here, APOE is linked to metabolic dysfunction-associated steatotic liver disease.