Through the use of WGCNA, a co-expression network modeling approach, to identify top modules and genes in NAFLD via transcriptomics, Lou et al. found several top hub genes including LUM, THBS2, FBN1, and EFEMP1, all of which were significantly upregulated in advanced fibrosing-NAFLD across several human cohorts and in ApoE−/− mice [103]. This evidence concerns the gene LUM and metabolic dysfunction-associated steatotic liver disease.