Zhu et al. implemented another variant of network modeling for new biomarkers of NAFLD via transcriptomics of rat liver by constructing miRNA-mRNA networks as well as constructing PPI (STRING) and pathway interaction networks, finding hub genes playing key roles in metabolism such as Cyp1a1, Cyp51, and Hmgcr, which have been previously correlated with NAFLD [98]. Here, HMGCR is linked to metabolic dysfunction-associated steatotic liver disease.