MMP12 and metabolic dysfunction-associated steatohepatitis: They found that the expression of genes involved in lipid metabolism and oxidative reactions was suppressed following diet-induced NASH in mice, while NASH-induced genes were highly enriched for the pathways responsible for ECM remodeling (Col1a1, Mmp12), cell adhesion, phagocytosis, and immune response (Ccr2, H2-ab1, and Lcn2).