This exotoxin has multiple cellular protein targets, which have critical roles in survival, proliferation, metastasis, and angiogenesis in cancer, by regulation of actin cytoskeletal dynamics, activation of protein kinases, cell cycle progression, cytokinesis, and the C10 regulator of kinases (CrkI, CrkII adaptor proteins) that are critical in the maintenance and formation of cellular focal adhesions and cytokinesis, and the glycolytic enzyme phosphoglycerate kinase 1 (PGK1) which is necessary for angiogenesis in cancer [87,88,89]. This evidence concerns the gene HK1 and cancer.