ANXA5 and malignant colon neoplasm: To determine the effect of the marine extracts on inducing apoptosis and to confirm our previous results from the Annexin V and MitoPotential assays, the activation of executioner caspases 3/7 and the initiator of the extrinsic apoptosis caspase 8 [26,27] was measured in colon cancer cells treated with different marine extracts for 24 h.