To further study the effect of marine extracts on the induction of apoptosis in colon cancer cell models (HGUE-C-1, HT-29, and SW-480), the Annexin V detection method was used, which allowed us to discriminate early apoptosis (cells expressing phosphatidylserine on the outer leaflet of the plasma membrane) from late apoptosis and necrosis (cells that have lost cell membrane integrity and are permeable to vital dyes). Here, ANXA5 is linked to colonic neoplasm.