These results are consistent with flow cytometry studies, showing that changes in p21/CIPI WAf1 and anti-apoptotic factors were more pronounced, indicating that, in the conditions and cells tested, cell cycle arrest, but not apoptosis, contributed to the antiproliferative and cytotoxic effects of IngC in malignant glioma cell lines. The gene discussed is CDKN1A; the disease is malignant glioma.