The circulating level of anti-mCRP autoantibodies in patients with lupus nephritis (LN) was closely associated with the score of their interstitial lesions.[18] Recently, Li et al[19] showed that a.a. 35 to 47, a sequence exposed only in mCRP, constitutes the major epitope recognized by anti-CRP autoantibodies in patients with LN and indicates that mCRP binds complement factor H and enhances its cofactor activity via a.a. 35 to 47, whereas autoantibodies against this epitope inhibit these actions and adversely affect LN. Here, CFH is linked to lobular neoplasia.