Previous studies have confirmed conventional risk factors for stroke, including hypertension, diabetes mellitus, hyperlipidemia, obesity, tobacco use, as well as alcohol drinking.[3–7] In recent years, several genome-wide association studies (GWAS) studies in European populations have successfully identified a new cardiovascular disease risk gene, the muscle RAS oncogene homolog (MRAS).[8,9]. Here, MRAS is linked to obesity due to melanocortin 4 receptor deficiency.