TRIM59 and lung carcinoma: Moreover, TRIM59 has been shown to be involved in the cytotoxicity of BCG (Bacillus Calmette-Guerin)-activated macrophages.[23] In human clinical studies, overexpression of TRIM59 has been found in colorectal cancer, breast cancer, hepatocellular carcinoma, lung cancer, gastric cancer, glioblastoma and others.