TNNT2 and familial dilated cardiomyopathy: At present, several genes have been implicated in the pathogenic generation of DCM, including titin (TTN), beta myosin heavy chain (MYH7), TNNT2, tropomyosin (TPM1), myosin binding protein C3 (MYBPC3), filamin C (FLNC), DSP, and lamin A/C (LMNA).[9] These genes mainly affect sarcomere proteins, cytoskeletal proteins, and ion channels.