A repurposing signal between misoprostol and an SNP on the type 2 prostaglandin E receptor (PTGER2) was detected by a workflow similar to that in this article; the associated PTGER2 PheWAS hits were significantly enriched for gastritis and duodenitis, and esophageal ulcer.42 More information on the design of NCT03617172 is available in Appendix Figure A3. Here, PTGER2 is linked to duodenitis.