Patients in the survivor group were significantly younger, had significantly less incidence of HE (P < .0001), had substantially lower levels of TB (P < .001), INR (P < .001), D‐dimer (P < .001), ferritin (P = .015) and WBC counts (P < .001), as well as lower MELD, MELD‐Na, CLIF‐C ACLF and COSSH‐ACLF scores (all P < .0001), but had higher AFP levels (P < .001) at admission compared to HBV‐ACLF patients who did not survive. This evidence concerns the gene AFP and hereditary elliptocytosis.