To date, there are no publications demonstrating a positive role for TNK2 in virus infection; several siRNA-based screens suggest that TNK2 is important for influenza A virus (IAV), vesicular stomatitis virus (VSV), and hepatitis C virus (HCV) infections (Fujimoto et al., 2011; König et al., 2010; Karlas et al., 2010; Lupberger et al., 2011), but no validation of these screening results have been reported. Here, TNK2 is linked to infection.