With respect to the relationship between structural variation of the BDNF gene and psychopathology, several studies have examined the association of BDNF haploinsufficiency with neurodevelopmental abnormalities in WAGR syndrome caused by 11p13 deletions near the location of the BDNF gene.26, 27, 28, 29, 30 A certain percentage of patients with WAGR syndrome exhibited deletion of the BDNF gene. This evidence concerns the gene BDNF and WAGR syndrome.