We found that mRNA of β‐catenin and Runx2 had significant increase after CCN1 stimulation.12 And they are critical transcription factors of early osteoblast differentiation.22 In this study, we were trying to focus more on the mechanism of how CCN1 stimulate the proliferation of osteoblasts itself in myeloma patients. Here, RUNX2 is linked to plasma cell myeloma.