EIF4E and neoplasm: 4E‐binding protein 1 (4E‐BP1) has tumor suppression effect by blocking mRNA translation and proliferation.33 This effect is realized by binding with eIF4E and inhibiting its activity, which can lead to decrease in overall translation rate.33 Thus 4E‐BP1 is kind of negative regulator for cell cycle progression, cell growth, and cell proliferation.