Interestingly, administration of tamoxifen to adult, 8-week old Alb-CreERT2+; KrasLSL-G12D; Ptenflox/flox mice lead to the development of HCC and HCC-precursor lesions, but not iCCA, whereas early postnatal tamoxifen injection on day 10 resulted in iCCA. The gene discussed is ALB; the disease is hepatocellular carcinoma.