AAV-mediated expression of KrasG12D and loss of Tp53 in the adult hepatocyte was only sufficient to drive tumorigenesis in this model when combined with an inflammatory stimulus by co-administration of DDC-diet, leading to development of iCCA, but also HCC with a similar incidence, as well as mixed iCCA/HCC tumors. Here, TP53 is linked to hepatocellular carcinoma.