EGFR and liver cancer: These studies include epigenetic changes [35], integration in the genome [36], protein expression [37], endothelial growth factor receptor (EGFR) signaling pathway [38], EGFR/ Hypoxia Inducible Factor-1α/vascular EGF (VEGF) pathways under hypoxic conditions [39,40,41], target gene discovery through copy number alteration [42], and genomic profiling of rare liver cancer [43].