In pancreatic cancer, the hPaf1 subunit of the human RNA polymerase II-associated factor (PAF) complex is overexpressed [188], and it interacts with and regulates the expression of CHD1 and the nuclear import of CHD1, facilitating the nucleosomal remodeling in pancreatic cancer cells [189]. The gene discussed is CHD1; the disease is familial pancreatic carcinoma.