AKT1 and breast cancer: Moreover, four Phase 1–2 clinical trials on BC patients, using PI3k/AKT inhibitors in combination or not with the pure antiestrogen fulvestrant (ClinicalTrials.gov Identifier: NCT01339442, NCT02260661 and NCT02077569) or a combination of the anticancer drug paclitaxel and the IL-8 receptor antagonist reparaxin (Identifier: NCT02001974) aimed to assess, as a secondary endpoint, FoxO3a expression, just ended.