Thus, to evaluate if LTG, by inducing FoxO3a expression, is able to restore the sensitivity to the anti-hormonal therapy also in vivo, female nude mice bearing TamR cells-derived tumor xenografts into the intrascapular region, were treated with LTG (20 mg/kg/day) on the basis of our in vitro results [28] and on the pertinent literature [36]. This evidence concerns the gene FOXO3 and neoplasm.