TGFB1 and cancer: Many of the key drivers of neoplastic progression, such as neutrophils, MDSCs, TAMs, and Tregs cells, work by secretion of pro-inflammatory cytokines, including IL-1, IL-6, TNF, and TGF-β (Figure 1B), providing a basis for a link between inflammation and cancer [138,139,140,141,142,143].