The TP53−/−, PTEN−/− mice did not progress past the pre‐invasive stage of the disease, suggesting that BRCA alterations are necessary for the progression of HGSC BRCA2−/−, TP53mut mice without PTEN alterations developed STIC, but none showed invasive tumors, the disease latency was much longer, and tumorigenesis was inefficient, suggesting that PTEN alterations are required for tumor initiation and progression, cooperating with BRCA and TP53 deletion/mutation. Here, PTEN is linked to neoplasm.