To clarify the molecular mechanisms through which serous carcinoma develops from the fallopian tubes, comprehensive genomic analyses of HGSC have been performed, as the Cancer Genome Atlas (TCGA).37 This analysis found that TP53 mutation was highly prevalent (96%), as expected, and additional genes including NF1, BRCA1, BRCA2, RB1, and CDK12 also had somatic mutations with relatively low but statistically significant frequencies. The gene discussed is TP53; the disease is serous adenocarcinoma.