The PHLPP2 (pleckstrin homology domain leucine rich repeat protein phosphatase 2) and FOXO1 (forkhead box O1) have been found to act as tumor suppressors in cancer cells negatively associating with AKT signaling pathway.17, 18, 19, 20 Therefore, our current study was designed to reveal whether MBNL1‐AS1 modulated miR‐135a/PHLPP2/FOXO1 axis to control the development and progression of BC. This evidence concerns the gene FOXO1 and cancer.