Furthermore, miR‐135a inh negatively induced the abnormal proliferation, apoptosis, and protein expressions of PHLPP2, FOXO1, and p‐AKT in MBNL1‐AS1 silencing BC cells, suggesting the novel MBNL1‐AS1/miR‐135a/PHLPP2/FOXO1 regulatory network in controlling the progression of BC mediated by the AKT signaling pathway. This evidence concerns the gene AKT1 and breast cancer.