In 161 patients with CRC with germline mutations, the most commonly mutated genes were EPCAM (40, 24.8%), MSH6 (39, 24.2%), followed by MLH1 (35, 21.7%), AXIN2 (35, 21.7%), POLD1 (28, 17.4%), and MSH2 (24, 14.9%). The gene discussed is MSH2; the disease is colorectal carcinoma.