This limitation has been reported previously.43, 44 Considering the five commonly mutated MMR genes associated with Lynch syndrome, namely, MLH1, MSH2, EPCAM, MSH6, and PMS2, the incidence of detected Lynch syndrome was higher up to 7.97% (120 in 1505 patients had at least one mutation in these five MMR genes). This evidence concerns the gene MSH2 and Lynch syndrome.