Three of these six patients with TGFBR2 germline mutations had the same second‐hit mutation in TGFBR2 (c.382_383delAA) in their tumors and these patients had similar clinicopathological features, including proximal tumor locations, early TNM stages and the EMAST(+)‐MSI‐H subtype (Figure S2). This evidence concerns the gene TGFBR2 and neoplasm.