A previous study presented the evidence that familial CRC originated partly from germline TGFBR2 mutations.62 However, another study did not find germline TGFBR2 mutation associated with patients with early‐onset CRC or HNPCC.63 We still found 15 patients with TGFBR2 germline mutations and six patients with solitary TGFBR2 germline mutations. Here, TGFBR2 is linked to hereditary nonpolyposis colon cancer.