MSH6 and Lynch syndrome: The other 70 patients with either EMAST(+) or MSI‐H tumors with clinical suspected Lynch syndrome, but no germline mutations identified through genetic testing were proposed as having Lynch‐like syndrome.39 In addition to germline mutations of MMR genes, Lynch‐like syndrome could result from somatic mutations of MMR genes or methylation of the MLH1 promotor.17 We analyzed the somatic mutations of five MMR genes (MLH1, MSH2, EPCAM, MSH6, PMS2) in the 70 patients with Lynch‐like syndrome and found 68 somatic mutations in 34 patients (Supplemental Excel).