PACAP also exerts neurotrophic and neuroprotective activities (Reglodi et al., 2012), promoting neurite outgrowth (Ogata et al., 2015), neuroprotection from ischemia (Ohtaki et al., 2006), and increases in hippocampal neurogenesis following environmental enrichment (Ago et al., 2011). The gene discussed is ADCYAP1; the disease is ischemia.