C‐C Motif Chemokine Ligand 22 (CCL22) is a potent chemoattractant for T‐lymphocytes, including Tregs.12, 13 It was known that tumor cells‐derived CCL22 functioned as a key factor for intratumoral recruitment of Tregs in several types of cancers, including liver cancer.8, 14 Blocking of CCL22 therefore may represent a novel approach for suppression of Tregs recruitment and subsequent tumor growth.15 Interestingly, bioinformatics analysis predicted that 3’UTR of CCL22 contained a putative‐binding site of miR‐23a seed sequence. Here, CCL22 is linked to liver cancer.