Previously, it was demonstrated that upregulated CCL22 was essential for Tregs recruitment and venous metastases of HBV+ HCC.8 Furthermore, TGF‐β/miR‐34a axis was identified to play a crucial role in the expression of CCL22.8 Our study provided a novel mechanism underlying CCL22 modulation by revealing the role of p65/miR‐23a axis. The gene discussed is TGFB1; the disease is hepatocellular carcinoma.