Given that CCL22 acted as an essential attractive signal of Tregs recruitment in various cancers,14, 20, 21 and that Foxp3 was the highly specific marker of Tregs, higher CCL22 and Foxp3 levels in HBV+ tumor implied higher intratumoral Tregs infiltration than HBV‐ tumors. This evidence concerns the gene FOXP3 and cancer.