In this study, after overexpression of Bcl‐2 in CRC cells transfected with miR‐498 mimic, we found that Bcl‐2 played an oncogenic role in CRC cells, as evidenced by their restored proliferation and survival and reduced apoptosis, in contrast with the function of miR‐498. The gene discussed is BCL2; the disease is colorectal carcinoma.