For this purpose, we designed a multicenter and observational study of a cohort of patients with acute ischemic stroke in order to study the association of serum levels of GF (vascular endothelial growth factor [VEGF], [G-CSF], brain-derived neurotrophic factor [BDNF], angiopoietin 1 [Ang-1]) and stromal-derived factor-1α [SDF-1α] with the functional outcome and reduction of lesion volume of ischemic stroke patients during a follow-up period of 1 year. This evidence concerns the gene BDNF and ischemic stroke.