The conformational change of vWF in blood flow from a globular state to an elongated state is crucial to a series of arterial thrombosis relevant processes, including the elevated absorption of vWF on the collagen surface,18 the regulation of the vWF size through ADAMTS13,60 the formation of vWF nets to capture fast transit platelets,9,24 and so on. Here, VWF is linked to Arterial thrombosis.