It is reported that mouse models of high‐fat diet and T2DM exhibit not only depressive‐like behavior but also insulin resistance in the brain.24, 25, 26, 27 In mice with brain‐specific knockout of the insulin receptor, brain insulin resistance induces decreased dopamine turnover, leading to anxiety and depressive‐like behaviors.28 In human, it has been conceived that peripheral insulin resistance metastasizes to the brain.29 Peripheral insulin resistance causes hyperinsulinemia, which enhances lipolysis. The gene discussed is INSR; the disease is Insulin resistance.