It is known that exercise in patients with T2DM not only improves peripheral insulin resistance but also lowers HbA1c values.45, 46 In addition, exercise improves brain structural abnormalities and is associated with prevention of depression in depressed patients.47, 48 However, use of DPP‐4 inhibitors provides a lower risk of depression compared to nonuse of DPP‐4 inhibitors. This evidence concerns the gene DPP4 and Insulin resistance.