Thus, given that the baseline demographic for age was statistically significantly higher in patients with CRSwNP than in control and CRSsNP patients; and multivariate analysis also demonstrated that, apart from the disease status, only age significantly influenced the methylation ratio of specifically CpG3 site within the TSLP promoter, it is possible that the observed effects on methylation within the TSLP promoter may at least partly be age-related. Here, TSLP is linked to chronic rhinosinusitis without nasal polyps.