IGHE and chronic rhinosinusitis without nasal polyps: While one study has demonstrated significant overexpression of TSLP mRNA in NP tissues from CRSwNP patients compared to nasal mucosa from CRSsNP and control subjects [10], another study has shown that the numbers of immunohistochemically stained TSLP+ nasal epithelial cells were significantly increased in NP tissues from atopic subjects compared to non-atopic subjects and also strongly correlated with the number of tissue eosinophils and IgE levels in NP tissue [11].