Although these cell lines share mutual characteristics, i.e. both are luminal A (ER-positive, PgR-positive, and HER2-negative) (Kao et al., 2009; Holliday and Speirs, 2011), a difference between the cell lines is that the tumor type of MCF-7 cells is metastatic adenocarcinoma, while that of T-47D is invasive ductal carcinoma (Kao et al., 2009). This evidence concerns the gene ERBB2 and neoplasm.