Furthermore, expression of a potential negative regulator of E2F6 microRNA-185 (miR-185) is downregulated in triple-negative breast cancer (i.e. negative for estrogen ER, progesterone PgR, and human epidermal growth factor receptor HER2/ERBB2) and associated with poor prognosis (Tang et al., 2014). This evidence concerns the gene ERBB2 and triple-negative breast carcinoma.