MYC and alcohol dependence: In HeLa cell clones, the DEGs were found to be involved in protein metabolism, urea cycle, chaperonin-mediated protein folding, G protein signalling, calcium pathway, copper homeostasis, chromatin organization, alcoholism, Wnt signalling, PI3K-Akt signalling, C-Myc transcriptional repression, cellular senescence, amyloid fiber formation, DNA methylation, meiosis, hemostasis, and mRNA 3′ UTR mediated regulation (Table 6).