A study in 19 HNSCC patients by Haque et al. 20, using a quantitative real-time polymerase chain reaction array that interrogates lncRNA with established involvement in numerous cancers, uncovered that low MEG3 expression of seven differential expression lncRNA, including SPRY4-IT1, HEIH, LUCAT1, LINC00152, HAND2-AS1, MEG3, and TERC, was related to more favorable 3-year RFS. Here, SPRY4 is linked to head and neck squamous cell carcinoma.