Intriguingly, we discovered that TAA-induced liver damage (increased AST and ALT levels; Fig. 1D,G; day 1–3 vs. day 0, *P < 0.05, **P < 0.01, ***P < 0.001; TAA vs. vehicle, #P < 0.05, ##P < 0.01, ###P < 0.001) was associated with the induction of thrombocytopenia (Fig. 1E,H, day 1–3 vs. day 0, *P < 0.05, **P < 0.01, ***P < 0.001; TAA vs. vehicle, #P < 0.05, ##P < 0.01, ###P < 0.001) and relatively higher anti-PLT Ig levels (Fig. 1F,I, *P < 0.05 vs. day 0; #P < 0.05, TAA vs. vehicle) in both rat (Fig. 1D–F) and mouse (Figs. 1G–I and 2A,B) models. The gene discussed is GPT; the disease is Thrombocytopenia.