TLE1 and acute lymphoblastic leukemia: Four of the six SNPs were validated in the replication series (P < 0.05, by additive logistic regression test): for all B-ALL at 9q21.3 (rs76925697, nearest gene TLE1), for HD ALL at 5q31.1 (rs886285, C5orf56) and 6p21.31 (rs210143, BAK1), and for ETV6-RUNX1-positive ALL at 17q21.32 (rs10853104, IGF2BP1) (Table 1 and Supplementary Tables 2, 4 and 5).