LINC01111 and pachyonychia congenita: To investigate the biological function of LINC01111 in PC, we used a lentiviral system to establish stable LINC01111-upregulated (LINC01111-UP) and LINC01111-knockdown (LINC01111-KD) PC cells, and the qRT-PCR results confirmed the functioning system (Fig. 2a).