We isolated cardiac tissues from ISO-treated 8-week-old mice, and results showed that GATA4 level was significantly enhanced in ISO-treated cKO mice (Fig. 6a, b), suggesting that activation of GATA4 mediates the hypertrophic cardiomyopathy in Kindlin-2 cKO mice. Here, FERMT2 is linked to hypertrophic cardiomyopathy.