Taken together, we suggested that deletion of cardiac Kindlin-2 leads to the dissociation of SUV39H1 from the GATA4 promoter and in turn H3K9 methylation is erased, leading to the reactivation of GATA4. Activation of GATA4 induces the cardiac hypertrophy (Fig. 7). The gene discussed is FERMT2; the disease is cardiac hypertrophy.