Reviewing previously reported GLI3 mutation subjects with GCPS or oral-facial-digital syndrome indicates that a small minority of these patients also display micropenis (Kroisel et al., 2001; Johnston et al., 2010), cryptorchidism (Kroisel et al., 2001; Johnston et al., 2010), or anosmia (Johnston et al., 2010). This evidence concerns the gene GLI3 and orofaciodigital syndrome.