ADNP and cancer: Given that ADNP was found to be an essential gene for cancer cell line viability specifically in those cell lines with a gene expression profile associated with poor prognosis as illustrated in Fig. 3c (p = 0.02, r = −0.4) we next examined the effect of ADNP on tumour cell proliferation and growth in order to begin to investigate the mechanisms by which ADNP affects HGSOC genesis and progression.