To evaluate the role of S100P in E-cadherin associated GC, we knocked down its expression by specific small interfering RNA (siRNA) in GC cells expressing either functional (MKN74 and NCI-N87) or dysfunctional E-cadherin (KATOIII and MKN45) (Additional file 2: Table S2 [24, 25];). Here, CDH1 is linked to gastric cancer.